In vitrogrowth factor release from injectable calcium phosphate cements containing gelatin microspheres

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In vitro growth factor release from injectable calcium phosphate cements containing gelatin microspheres.

To improve the in vivo resorption of an injectable calcium phosphate cement (CPC) for bone tissue engineering purposes, in previous experiments macroporosity was introduced by the in situ degradation of incorporated gelatin microspheres. Gelatin microspheres are also suitable carriers for osteoinductive drugs/growth factors, where release occurs concomitantly with degradation of the hydrogel. I...

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Introduction of gelatin microspheres into an injectable calcium phosphate cement.

For tissue engineered bone constructs, calcium phosphate cement (CPC) has a high potential as scaffold material because of its biocompatibility and osteoconductivity. However, in vivo resorption and tissue ingrowth is slow. To address these issues, microspheres can be incorporated into the cement, which will create macroporosity after in situ degradation. The goal of this study was to investiga...

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ژورنال

عنوان ژورنال: Journal of Biomedical Materials Research Part A

سال: 2009

ISSN: 1549-3296,1552-4965

DOI: 10.1002/jbm.a.32263